Loading...
Search for:
hormones
0.004 seconds
Biosensor for Fast Detection (Based on Thyroid Hormones)
, M.Sc. Thesis Sharif University of Technology ; Abdekhodaie, Mohammad Jafar (Supervisor)
Abstract
Thyroid gland is one of the important internal organs of the body that is responsible for T3 and T4 hormones secretion. Concentration of these hormones directly influences growth of body, thus measurement concentration of thyroid hormones is one of the most common experiments all of the world, specially in our country that Hypothyroidism is common among people. Secretion of hormones in thyroid gland controlled by TSH (thyroid Stimulating Hormone) that released from Pituitary gland. TSH concentration is opposite of level of thyroid secretion. Because of interconnected relationship between these three hormones, measurement of each of them is so important. Many researches for developing...
Comparison of the effects of growth hormone on acylated ghrelin and following acute intermittent exercise in two levels of obesity
, Article Tehran University Medical Journal ; Volume 71, Issue 5 , 2013 , Pages 330-339 ; 16831764 (ISSN) ; Tabrizi, A ; Sharif University of Technology
2013
Abstract
Background: The prevalence of obesity has risen enormously over the past few decad-es. Both food intake (Appetite) and energy expenditure can influence body weight. Acylated ghrelin enhances appetite, and its plasma level is suppressed by growth horm-one. The present study, examines the effects of an intermittent exercise with progress-ive intensities on acylated ghrelin, appetite, and growth hormone in inactive male students with two levels of obesity. Methods: Eleven inactive males were allocated into two groups on the basis of their body mass index (BMI). Six subjects in group one, BMI= 31.18±0.92 kg/m2, and five subjects in group two, BMI= 36.94±2.25 kg/m2, ran on the treadmill with...
The acute effects of intermittent treadmill running on hunger and plasma acylated ghrelin concentration in individuals with obesity
, Article Tehran University Medical Journal ; Volume 69, Issue 2 , 2011 , Pages 125-135 ; 16831764 (ISSN) ; Kordi, M ; Taghikhani, M ; Ravasi, A ; Gaeini, A ; Tabrizi, A ; Sharif University of Technology
Abstract
Background: Body weight is regulated by both food intake and energy expenditure. Ghrelin, a hormone produced by the stomach and pancreas, enhances appetite. This study was undertaken to determine the effects of intermittent treadmill running on acylated ghrelin and appetite in individuals with obesity. Methods: Nine inactive male students, with a mean age of 20.56±0.48 yrs, a body mass index of 32.68±0.84 kg/m2 and a maximum oxygen uptake of 34.21±1.48 ml/kg/min, participated in the study in two trials (control and exercise) in a counterbalanced, randomized design. The protocol included intermittent running with a constant intensity at 65% of VO2 max on a treadmill. Blood samples were...
Fabrication of 3D Graphene/Gold Porous Electrode for Biosensing Applications
, M.Sc. Thesis Sharif University of Technology ; Simchi, AbdolReza (Supervisor) ; Tamjid Shabestari, Elnaz (Supervisor)
Abstract
Today, the use of carbon nanostructures hybridized with noble metals has attracted considerable attention for the fabrication of bio-electrochemical sensors. Since the specific surface area has an immense effect on the sensing response, three-dimensional structures of graphene have a great capability to utilize in these sensors. In this research, three-dimensional graphene was provided on the porous nickel foam by chemical vapor deposition technique. By evaluation of raman spectroscopy, the time period of 20 minutes for solving of the carbon atoms into the nickel foam was selected as the main parameter of optimized conditions for the synthesis of graphene. Afterward, production of few-layer...
Modeling of melatonin behavior in major depression: A fuzzy logic modeling
, Article Applied Mechanics and Materials ; Volume 367 , June , 2013 , Pages 317-321 ; 16609336 (ISSN) ; 9783037857885 (ISBN) ; Osgouie, K. G ; Rashidnejhad, S ; Cheragh, M ; Sharif University of Technology
2013
Abstract
According to the world health organization, major depressive disorder (MDD) is considered as the fourth main cause of death and premature weakness in the whole world. Abnormality in the hormones and neurotransmitters level is the one of the main factors which may result in this disorder. In this article melatonin is chosen among these hormones, which is the most implicated to control sleep and depression. Because the measurement of melatonin is crucial important, the fuzzy logic approach as the mathematical method is utilized to making melatonin behavior model. In this paper, two effective factors on melatonin are modeled by fuzzy logic. This model is only a part of our project which is...
The effect of a training program on body composition, growth hormone, insulin and insulin-like growth factor 1 in overweight female college students
, Article Gazzetta Medica Italiana Archivio per le Scienze Mediche ; Volume 171, Issue 4 , 2012 , Pages 409-416 ; 03933660 (ISSN) ; Tabrizi, A ; Sharif University of Technology
Abstract
Aim. The aim of this study was to determine the effect of a training program on body composition, GH, IGF-1 and insulin in overweight and obese female college students. Methods. The 17 overweight college student females divided into 2 groups: Experimental group (E) with 3 sessions per week, 6 weeks duration (N=9,Age=18.9 ± 1.3,BMI= 28.8 ± 2.6), and non-exercising control group (C) (N=8, Age=19.3 ± 1.8, BMI=26.3 ± 0.9). All measures included Vo2max, body composition, IGF-1, GH and insulin were done at baseline and following the protocol. Results. The calorie intake increased in both groups when compared to the baseline. The Vo2max increased statistically significant in E, and decreased in C....
Sensitive voltammetric detection of melatonin in pharmaceutical products by highly conductive porous graphene-gold composites
, Article ACS Sustainable Chemistry and Engineering ; 2020 ; Hemmati, A ; Mohammadi, R ; Hatamie, A ; Tamjid, E ; Simchi, A ; Sharif University of Technology
American Chemical Society
2020
Abstract
This work presents a novel melatonin sensor based on unfunctionalized macroporous graphene networks decorated with gold nanoparticles for the differential pulse voltammetric detection of melatonin in pharmaceutical products. Highly porous graphene structures were prepared by metallic template-assisted chemical vapor deposition, and their active surface area and electrocatalytic activity were improved by electrochemical deposition of gold nanoparticles (50-250 nm) on their struts. The graphene-gold electrodes present a highly sensitive performance toward electro-oxidation of melatonin with a wide linear range of 0.05-50 μM, a low detection limit of 0.0082 μM (3σ/m), and a significant...
Noble metal nanostructures in optical biosensors: basics, and their introduction to anti-doping detection
, Article TrAC - Trends in Analytical Chemistry ; Volume 100 , 2018 , Pages 116-135 ; 01659936 (ISSN) ; Sahandi Zangabad, P ; Mohammadi, H ; Sadroddini, M ; Jafari, Z ; Mahlooji, N ; Abbaspour, S ; Gholami, S ; Ghanbarpoor, M ; Pashazadeh, R ; Beyzavi, A ; Karimi, M ; Hamblin, M. R ; Sharif University of Technology
Elsevier B.V
2018
Abstract
Nanotechnology has illustrated significant potentials in biomolecular-sensing applications; particularly its introduction to anti-doping detection is of great importance. Illicit recreational drugs, substances that can be potentially abused, and drugs with dosage limitations according to the prohibited lists announced by the World Antidoping Agency (WADA) are becoming of increasing interest to forensic chemists. In this review, the theoretical principles of optical biosensors based on noble metal nanoparticles, and the transduction mechanism of commonly-applied plasmonic biosensors are covered. We review different classes of recently-developed plasmonic biosensors for analytic determination...
Melatonin as a powerful bio-antioxidant for reduction of graphene oxide
, Article Journal of Materials Chemistry ; Volume 21, Issue 29 , 2011 , Pages 10907-10914 ; 09599428 (ISSN) ; Akhavan, O ; Irajizad, A ; Sharif University of Technology
2011
Abstract
Graphene is usually synthesized through deoxygenation of graphene oxide (GO) by hydrazine as the most common and one of the strongest reducing agents. But, due to the high toxicity of hydrazine, it is not a promising reductant in large-scale production of graphene. Here, for the first time, we used melatonin (MLT), as a powerful antioxidant and a biocompatible competitor of hydrazine in reduction of GO suspension. X-ray photoelectron spectroscopy (XPS), current-voltage and optical characteristics of the sheets indicated that the deoxygenation efficiency of the GO suspensions by MLT and under heating in an alkaline condition for 3 h was comparable with the efficiency obtained by hydrazine in...
Wrapping bacteria by graphene nanosheets for isolation from environment, reactivation by sonication, and inactivation by near-infrared irradiation
, Article Journal of Physical Chemistry B ; Volume 115, Issue 19 , 2011 , Pages 6279-6288 ; 15206106 (ISSN) ; Ghaderi, E ; Esfandiar, A ; Sharif University of Technology
American Chemical Society
2011
Abstract
Bioactivity of Escherichia coli bacteria (as a simple model for microorganisms) and interaction of them with the environment were controlled by their capturing within aggregated graphene nanosheets. The oxygen-containing functional groups of chemically exfoliated single-layer graphene oxide nanosheets were reduced by melatonin as a biocompatible antioxidant. While each one of the graphene (oxide) suspension and melatonin solution did not separately show any considerable inactivation effects on the bacteria, aggregation of the sheets in the melatonin-bacterial suspension resulted in trapping the bacteria within the aggregated sheets, i.e., a kind of inactivation. The bacteria trapped within...
Plant hormones as signals in arbuscular mycorrhizal symbiosis
, Article Critical Reviews in Biotechnology ; Vol. 34, issue. 2 , 2014 , p. 123-133 ; Abrishamchi, A ; Khoshbakht, K ; Niknam, V ; Sharif University of Technology
Abstract
Arbuscular mycorrhizal (AM) fungi are non-specific symbionts developing mutual and beneficial symbiosis with most terrestrial plants. Because of the obligatory nature of the symbiosis, the presence of the host plant during the onset and proceeding of symbiosis is necessary. However, AM fungal spores are able to germinate in the absence of the host plant. The fungi detect the presence of the host plant through some signal communications. Among the signal molecules, which can affect mycorrhizal symbiosis are plant hormones, which may positively or adversely affect the symbiosis. In this review article, some of the most recent findings regarding the signaling effects of plant hormones, on...
Possible role for growth hormone in suppressing acylated ghrelin and hunger ratings during and after intermittent exercise of different intensities in obese individuals
, Article Acta Medica Iranica ; Vol. 52, Issue. 1 , 2014 , pp. 29-37 ; ISSN: 1735-9694 ; Kordi, M. R ; Taghikhani, M ; Ravasi, A. A ; Gaeini, A. A ; Tabrizi, A ; Sharif University of Technology
Abstract
Body weight is influenced by both food intake and energy expenditure. Acylated ghrelin enhances appetite, and its circulating level is suppressed by Growth Hormone. Data on the acylated ghrelin responses to exercise of different intensities in obese individuals are currently not available. This study examined the effects of an intermittent exercise protocol on acylated ghrelin levels and hunger ratings in obese people. Nine inactive male ran on the treadmill at 0900 with progressive intensities of 50, 60, 70, and 80% of VO2max for 10, 10, 5, and 2 min respectively. Blood samples were collected before the exercise at 0845 (-15 min as the resting values), after each workload (10, 23, 31, and...
Identification of catecholamine neurotransmitters using fluorescence sensor array
, Article Analytica Chimica Acta ; Volume 917 , April , 2016 , Pages 85–92 ; 00032670 (ISSN) ; Hormozi Nezhad, M. R ; Mahmoudi, M ; Sharif University of Technology
Elsevier
2016
Abstract
A nano-based sensor array has been developed for identification and discrimination of catecholamine neurotransmitters based on optical properties of their oxidation products under alkaline conditions. To produce distinct fluorescence response patterns for individual catecholamine, quenching of thioglycolic acid functionalized cadmium telluride (CdTe) quantum dots, by oxidation products, were employed along with the variation of fluorescence spectra of oxidation products. The spectral changes were analyzed with hierarchical cluster analysis (HCA) and principal component analysis (PCA) to identify catecholamine patterns. The proposed sensor could efficiently discriminate the individual...
A perspective to the correlation between brain insulin resistance and alzheimer: medicinal chemistry approach
, Article Current Diabetes Reviews ; Volume 15, Issue 4 , 2019 , Pages 255-258 ; 15733998 (ISSN) ; Bagherzadeh, M ; Rabiee, M ; Sharif University of Technology
Bentham Science Publishers
2019
Abstract
Substantial terms have been recognized on the associated risk elements, comorbidities as well as, putative pathophysiological processes of Alzheimer disease and related dementias (ADRDs) as well as, type 2 diabetes mellitus (T2DM), a few from greatest important disease from the moments. Very much is considered regarding the biology and chemistry of each predicament, nevertheless T2DM and ADRDs are an actually similar pattern developing from the similar origins of maturing or synergistic conditions connected by aggressive patho-corporeal terms and continues to be ambiguous. In this depth-critique article, we aimed to investigate all possibilities and represented a novel and applicable...
A perspective to the correlation between brain insulin resistance and Alzheimer: Medicinal chemistry approach
, Article Current Diabetes Reviews ; Volume 15, Issue 4 , 2019 , Pages 255-258 ; 15733998 (ISSN) ; Bagherzadeh, M ; Rabiee, M ; Sharif University of Technology
Bentham Science Publishers
2019
Abstract
Substantial terms have been recognized on the associated risk elements, comorbidities as well as, putative pathophysiological processes of Alzheimer disease and related dementias (ADRDs) as well as, type 2 diabetes mellitus (T2DM), a few from greatest important disease from the moments. Very much is considered regarding the biology and chemistry of each predicament, nevertheless T2DM and ADRDs are an actually similar pattern developing from the similar origins of maturing or synergistic conditions connected by aggressive patho-corporeal terms and continues to be ambiguous. In this depth-critique article, we aimed to investigate all possibilities and represented a novel and applicable...
Identification of catecholamine neurotransmitters using fluorescence sensor array
, Article Analytica Chimica Acta ; Volume 917 , 2016 , Pages 85-92 ; 00032670 (ISSN) ; Hormozi Nezhad, M. R ; Mahmoudi, M ; Sharif University of Technology
Elsevier B.V
2016
Abstract
A nano-based sensor array has been developed for identification and discrimination of catecholamine neurotransmitters based on optical properties of their oxidation products under alkaline conditions. To produce distinct fluorescence response patterns for individual catecholamine, quenching of thioglycolic acid functionalized cadmium telluride (CdTe) quantum dots, by oxidation products, were employed along with the variation of fluorescence spectra of oxidation products. The spectral changes were analyzed with hierarchical cluster analysis (HCA) and principal component analysis (PCA) to identify catecholamine patterns. The proposed sensor could efficiently discriminate the individual...
Synthesis of a novel magnetic starch-alginic acid-based biomaterial for drug delivery
, Article Carbohydrate Research ; Volume 487 , 2020 ; Forouzandehdel, S ; Rezghi Rami, M ; Sharif University of Technology
Elsevier Ltd
2020
Abstract
The magnetic composite hydrogel was fabricated by the graft copolymerization of itaconic acid (IA) onto starch and Alginic acid in the presence graphene sheets (Gr) and Fe3O4 nanoparticles (Fe3O4@Gr-IA/St-Alg) for Guaifenesin (GFN) delivery and wound healing. The Fe3O4@Gr-IA/St-Alg biomaterial is a hydrogel network endowed the material with magnetic property. In addition, GFN not only achieved effectively bound to the magnetic hydrogel, but also released in a controlled manner. The using external magnetic field has significantly positive influence on the drug release rate. To close, these hydrogel drug carriers offer a favorable platform for magnetically targeted drug delivery as well as a...
Opposite trends of GAS6 and GAS6-AS expressions in breast cancer tissues
, Article Experimental and Molecular Pathology ; Volume 118 , 2021 ; 00144800 (ISSN) ; Hussen, B. M ; Taheri, F ; Sattari, A ; Yousefi, H ; Omrani, M. D ; Nazer, N ; Ghafouri Fard, S ; Taheri, M ; Sharif University of Technology
Academic Press Inc
2021
Abstract
Growth arrest-specific gene 6 (GAS6) is a growth factor-like cytokine whose function is related with vitamin K. This protein interacts with receptor tyrosine kinase proteins such as Tyro3, Axl, and TAM Receptor family, therefore affecting the tumorigenic processes via different mechanisms. GAS6-antisense 1 (GAS6-AS1) is a long non-coding RNAs (lncRNAs) that is transcribed from a genomic regions nearby GAS6. This lncRNA is also implicated in the pathobiology of cancer. We intended to judge the role of GAS6 and GAS6-AS1 in the pathogenesis of breast cancer through appraisal of their expression levels in breast cancer tissues and their paired neighboring non-cancerous samples. Expression of...