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Machine learning approach for carrier surface design in carrier-based dry powder inhalation
, Article Computers and Chemical Engineering ; Volume 151 , 2021 ; 00981354 (ISSN) ; Alishiri, M ; Lau, R ; Sharif University of Technology
Elsevier Ltd
2021
Abstract
In this study, a machine learning approach was applied to evaluate the impact of operating and design variables on dry powder inhalation efficiency. Emitted dose and fine particle fraction data were extracted from the literature for a variety of drug and carrier combinations. Carrier surface properties are obtained by image analysis of SEM images reported. Models combining artificial neural network and genetic algorithm were developed to determine the emitted dose and fine particle fraction. Design strategies for the carrier surface were also proposed to enhance the fine particle fractions. © 2021 Elsevier Ltd
Challenges and future prospects for the delivery of biologics: oral mucosal, pulmonary, and transdermal routes
, Article AAPS Journal ; Volume 19, Issue 3 , 2017 , Pages 652-668 ; 15507416 (ISSN) ; Fathe, K. R ; Brunaugh, A ; Ferrati, S ; Li, S ; Montenegro Nicolini, M ; Mousavikhamene, Z ; McConville, J. T ; Prausnitz, M. R ; Smyth, H. D. C ; Sharif University of Technology
Springer New York LLC
2017
Abstract
Biologic products are large molecules such as proteins, peptides, nucleic acids, etc., which have already produced many new drugs for clinical use in the last decades. Due to the inherent challenges faced by biologics after oral administration (e.g., acidic stomach pH, digestive enzymes, and limited permeation through the gastrointestinal tract), several alternative routes of administration have been investigated to enable sufficient drug absorption into systemic circulation. This review describes the buccal, sublingual, pulmonary, and transdermal routes of administration for biologics with relevant details of the respective barriers. While all these routes avoid transit through the...