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d-penicillamine
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A colorimetric assay for d-Penicillamine in urine and plasma samples based on the aggregation of gold nanoparticles
, Article Journal of the Iranian Chemical Society ; Vol. 11, issue. 5 , Dec , 2014 , p. 1249-1255 ; Azargun, M ; Fahimi-Kashani, N ; Sharif University of Technology
Abstract
We report herein the development of a highly sensitive colorimetric method for detection of d-Penicillamine using citrate-capped gold nanoparticles (AuNPs). This assay relies upon the distance-dependent of gold nanoparticles surface plasmon resonance band of gold nanoparticles. By replacing the thiol-containing chelator drug, d-Penicillamine, with citrate on the gold nanoparticles surface, a new peak appearing at a longer wavelength intensifies and shifts further to the red from the original peak position due to aggregation of gold nanoparticles which depends on ionic strength, gold nanoparticles and d-Penicillamine concentration. During this process, the plasmon band at 521 nm decreases...
Electrocatalytic oxidation of penicillamine at a carbon paste electrode modified with cobalt salophen
, Article Journal of Electroanalytical Chemistry ; Volume 565, Issue 1 , 2004 , Pages 95-101 ; 15726657 (ISSN) ; Souri, A ; Khajehsharifi, H ; Sharif University of Technology
Elsevier
2004
Abstract
Electrocatalytic oxidation of penicillamine (PA) at a carbon paste electrode chemically modified with cobalt salophen as a schiff base complex (CoSal) was thoroughly investigated. The results of cyclic voltammetry (CV) and polarization studies were used for the prediction of the mechanism of electrochemical oxidation of PA mediated with CoSal at the surface of a modified electrode. The performance of the modified electrode was compared with those of electrodes modified with cobalt phthalocyanine (CoPc). In comparison, CoSal appears to be considerably more effective as a catalyst for reduction of the overpotential of the anodic oxidation of PA, resulting in a very sharp anodic CV peak at...
Spectrophotometric Determination of D - L-Penicillamine Using Red Shift on the Surface Plasmon Resonance Band of Au Nanoparticles
, M.Sc. Thesis Sharif University of Technology ; Hormozi Nezhad, Mohammad Reza (Supervisor)
Abstract
We report herein the development of a highly sensitive colorimetric method for detection of D- Penicillamine using citrate capped gold nano particles (Au-NPs) .This assay relies upon the distance-dependent of gold nanoparticles surface plasmonic resonance band of gold nanoparticles. By replacing the thiol-containg chelator drug, D-Penicillamine, with citrate on the gold nano particles surface, a new peak appearing at a longer wavelength intensifies and shifts further to the red from the original peak position which depends on ionic strength, D- Penicillamine and gold nanoparticles. The ratio intensities of absorbance at longer wavelength (630 nm) to original wavelength (521 nm) allow the...
Spectrofluorimetric Determination of D-penicillamine Using FITC-capped Gold Nanoparticles Via Flourescence Resonance Energy Transfer Mechanism
, M.Sc. Thesis Sharif University of Technology ; Hormozi Nezhad, Mohammad Reza (Supervisor)
Abstract
Recently, fluorescence resonance energy transfer (FRET) based assay through employing gold nanoparticles have been developed for sensitive and selective detection of various analytes [1,2]. These are due to the extremely high extinction coefficient of Au NPs, which induces fluorescence quenching of the attached fluorophores as a result FRET ; a process which is inversely proportional to the sixth power of the distance between fluorophore and quencher [3]. Upon the addition of the analytes with much stronger affinity for Au NPs, the fluorophore molecules are detached from the surface of the Au NPs results in an increase of fluorescence intensity, which is in direct relation with...
Selective voltammetric determination of d-penicillamine in the presence of tryptophan at a modified carbon paste electrode incorporating TiO2 nanoparticles and quinizarine
, Article Journal of Electroanalytical Chemistry ; Volume 644, Issue 1 , Jan , 2010 , Pages 1-6 ; 15726657 (ISSN) ; Beitollahi, H ; Taleat, Z ; Naeimi, H ; Taghavinia, N ; Sharif University of Technology
2010
Abstract
A carbon paste electrode (CPE) chemically modified with TiO2 nanoparticles and quinizarine (QZ) was used as a selective electrochemical sensor for the simultaneous determination of minor amounts of d-penicillamine (D-PA) and tryptophan (Trp). This modified electrode showed very efficient electrocatalytic activity for anodic oxidation of both d-PA and Trp. Substantial decreases of anodic overpotentials for both compounds made this analysis possible. Results of square wave voltammetry (SWV) using this modified electrode showed two well-resolved anodic waves for the oxidation of d-PA and Trp, which makes the simultaneous determination of both compounds possible. The peak potential for the...