Loading...
Search for:
comet-assay
0.008 seconds
Cell shape affects nanoparticle uptake and toxicity: An overlooked factor at the nanobio interfaces
, Article Journal of Colloid and Interface Science ; Volume 531 , 2018 , Pages 245-252 ; 00219797 (ISSN) ; Ghahremani, M. H ; Hashemi, F ; Hormozi Nezhad, M. R ; Raoufi, M ; Zanganeh, S ; Atyabi, F ; Dinarvand, R ; Mahmoudi, M ; Sharif University of Technology
Academic Press Inc
2018
Abstract
Hypothesis: It is now being increasingly accepted that cells in their native tissue show different morphologies than those grown on a culture plate. Culturing cells on the conventional two-dimensional (2D) culture plates does not closely resemble the in vivo three-dimensional (3D) structure of cells which in turn seems to affect cellular function. This is one of the reasons, among many others, that nanoparticles uptake and toxicology data from 2D culture plates and in vivo environments are not correlated with one another. In this study, we offer a novel platform technology for producing more in vivo-like models of in vitro cell culture. Experiments: The normal fibroblast cells (HU02) were...