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Preparation and Evaluation of Nanopolysaccharides- & Polysaccharides-Anticancer Drugs Conjugates
, Ph.D. Dissertation Sharif University of Technology ; Pourjavadi, Ali (Supervisor)
Abstract
In recent years, cancer is the second leading cause of human death. Cancer treatment is based on surgery, chemotherapy and radiation therapy. Choice of treatment method depends on the degree of progression and type of cancer. However, the goal is destruction of cancer cells and minimal harmful side effects on healthy cells. In this thesis two types of polysaccharide-anticancer drug conjugate were prepared and evaluated for radiation therapy and chemotherapy; chitosan- and DTPA modified chitosan – Gallium 66 conjugates for radiation therapy and nano diacid starch –cisplatin conjugate for chemotherapy. Chitosan –gallium 66 conjugate was prepared in radiochemical purity higher than 99% at...
Investigation of Anticancer Drug Metabolism in Saccharomyces Cerevisiae as a Drug Resistance Model
, M.Sc. Thesis Sharif University of Technology ; Yaghmaei, Soheila (Supervisor) ; Sardari, Soroush (Supervisor)
Abstract
Cancer is a life-threatening group of diseases that arises from the uncontrolled growth and division of cells in the body. Treatment options for cancer include surgery, chemotherapy, radiation therapy, immunotherapy, targeted therapy, and hormone therapy. However, resistance to anticancer drugs can develop through a variety of mechanisms, such as the upregulation of drug efflux pumps and alterations in DNA repair mechanisms. One common mechanism of drug resistance is through changes in metabolism, where cancer cells switch to alternative metabolic pathways to survive and evade the effects of anticancer drugs. The development of new drugs targeting specific molecules and pathways involved in...
Study of Supramolecular Chemistry of Fullerene (C60) with Azobenzene Tweezer Linking to Biaza-Crown Macrocycles Coordinated to Zinc Tetraphenylporphyrin
, M.Sc. Thesis Sharif University of Technology ; Ghanbari, Bahram (Supervisor)
Abstract
In this project, in continuation of a PhD resreach undertaken in this research group in 2017, the synthesis and study of two new tweezer and linker molecule bearing azobenzene moiety were carried out, characterized by applying IR spectroscopy, ¹H and ¹³C {¹H} NMR, fluorescence spectroscopy, UV-visible spectroscopy, elemental analysis and X-ray crystallography. Firstly, interaction of T2 with meso-tetraphenylporphyrinato zinc(II) and aluminium tetraphenylporphyrinato were studied using the fluorescence spectroscopy. The formation constant of T2 in cis and trans isomer with ZnTPP was measured as 5.1(±0.4) ×108 and 2.0×108(±1074) dm6mol-2, respectively. The formation constant of T2 in with...
The role of polyethylene glycol size in chemical spectra, cytotoxicity, and release of pegylated nanoliposomal cisplatin
, Article Assay and Drug Development Technologies ; Volume 17, Issue 5 , 2019 , Pages 231-239 ; 1540658X (ISSN) ; Jamehbozorgi, S ; Akbarzadeh, I ; Aghabozorg, H. R ; Amini, A ; Sharif University of Technology
Mary Ann Liebert Inc
2019
Abstract
This study aimed to synthesize methoxy polyethylene glycol propionaldehyde (mPEG20,000-ALD) for the preparation of PEGylated nanoliposomal cisplatin. Nanocarriers such as liposomes are developed for a wide range of drug delivery systems. PEG with high molecular weight (Mw) is used to coat the liposomes. In this study, simulated Fourier transform infrared (FTIR) spectra of mPEG-ALD were obtained using density functional theory (DFT) calculations and then compared with actual FTIR spectrum of mPEG20,000-ALD (Mw = 20 kDa). We found that the intensity of C = O stretching vibration at 1,700 cm-1 related to the carbonyl functional group of mPEG20,000-ALD was very weak. The results of DFT...
Carbon nanotubes part II: A remarkable carrier for drug and gene delivery
, Article Expert Opinion on Drug Delivery ; Volume 12, Issue 7 , 2015 , Pages 1089-1105 ; 17425247 (ISSN) ; Solati, N ; Ghasemi, A ; Estiar, M. A ; Hashemkhani, M ; Kiani, P ; Mohamed, E ; Saeidi, A ; Taheri, M ; Avci, P ; Aref, A. R ; Amiri, M ; Baniasadi, F ; Hamblin, M. R ; Sharif University of Technology
Informa Healthcare
2015
Abstract
Introduction: Carbon nanotubes (CNT) have recently been studied as novel and versatile drug and gene delivery vehicles. When CNT are suitably functionalized, they can interact with various cell types and are taken up by endocytosis.Areas covered: Anti-cancer drugs cisplatin and doxorubicin have been delivered by CNT, as well as methotrexate, taxol and gemcitabine. The delivery of the antifungal compound amphotericin B and the oral administration of erythropoietin have both been assisted using CNT. Frequently, targeting moieties such as folic acid, epidermal growth factor or various antibodies are attached to the CNT-drug nanovehicle. Different kinds of functionalization (e.g., polycations)...
Superparamagnetic iron oxide nanoparticles (SPIONs): Development, surface modification and applications in chemotherapy
, Article Advanced Drug Delivery Reviews ; Volume 63, Issue 1-2 , January–February , 2011 , Pages 24-46 ; 0169409X (ISSN) ; Sant, S ; Wang, B ; Laurent, S ; Sen, T ; Sharif University of Technology
2011
Abstract
At present, nanoparticles are used for various biomedical applications where they facilitate laboratory diagnostics and therapeutics. More specifically for drug delivery purposes, the use of nanoparticles is attracting increasing attention due to their unique capabilities and their negligible side effects not only in cancer therapy but also in the treatment of other ailments. Among all types of nanoparticles, biocompatible superparamagnetic iron oxide nanoparticles (SPIONs) with proper surface architecture and conjugated targeting ligands/proteins have attracted a great deal of attention for drug delivery applications. This review covers recent advances in the development of SPIONs together...
Doxorubicin/cisplatin-loaded superparamagnetic nanoparticles as a stimuli-responsive Co-delivery system for chemo-photothermal therapy
, Article International Journal of Nanomedicine ; Volume 14 , 2019 , Pages 8769-8786 ; 11769114 (ISSN) ; Zamani, M ; Vossoughi, M ; Iraji zad, A ; Sharif University of Technology
Dove Medical Press Ltd
2019
Abstract
Introduction: To date, numerous iron-based nanostructures have been designed for cancer therapy applications. Although some of them were promising for clinical applications, few efforts have been made to maximize the therapeutic index of these carriers. Herein, PEGylated silica-coated iron oxide nanoparticles (PS-IONs) were introduced as multipurpose stimuli-responsive co-delivery nanocarriers for a combination of dual-drug chemotherapy and photothermal therapy. Methods: Superparamagnetic iron oxide nanoparticles were synthesized via the sonochemical method and coated by a thin layer of silica. The nanostructures were then further modified with a layer of di-carboxylate polyethylene glycol...
Doxorubicin/cisplatin-loaded superparamagnetic nanoparticles as a stimuli-responsive Co-delivery system for chemo-photothermal therapy
, Article International Journal of Nanomedicine ; Volume 14 , 2019 , Pages 8769-8786 ; 11769114 (ISSN) ; Zamani, M ; Vossoughi, M ; Iraji zad, A ; Sharif University of Technology
Dove Medical Press Ltd
2019
Abstract
Introduction: To date, numerous iron-based nanostructures have been designed for cancer therapy applications. Although some of them were promising for clinical applications, few efforts have been made to maximize the therapeutic index of these carriers. Herein, PEGylated silica-coated iron oxide nanoparticles (PS-IONs) were introduced as multipurpose stimuli-responsive co-delivery nanocarriers for a combination of dual-drug chemotherapy and photothermal therapy. Methods: Superparamagnetic iron oxide nanoparticles were synthesized via the sonochemical method and coated by a thin layer of silica. The nanostructures were then further modified with a layer of di-carboxylate polyethylene glycol...
Brain-on-a-chip: Recent advances in design and techniques for microfluidic models of the brain in health and disease
, Article Biomaterials ; Volume 285 , 2022 ; 01429612 (ISSN) ; Shamloo, A ; Nasiri, R ; de Barros, N. R ; Wang, Z. Z ; Unluturk, B. D ; Libanori, A ; Ievglevskyi, O ; Diltemiz, S. E ; Sances, S ; Balasingham, I ; Seidlits, S. K ; Ashammakhi, N ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
Recent advances in biomaterials, microfabrication, microfluidics, and cell biology have led to the development of organ-on-a-chip devices that can reproduce key functions of various organs. Such platforms promise to provide novel insights into various physiological events, including mechanisms of disease, and evaluate the effects of external interventions, such as drug administration. The neuroscience field is expected to benefit greatly from these innovative tools. Conventional ex vivo studies of the nervous system have been limited by the inability of cell culture to adequately mimic in vivo physiology. While animal models can be used, their relevance to human physiology is uncertain and...