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cholesterol-blood-level
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A fuzzy expert system for prescribing atorvastatin optimum dose
, Article Koomesh ; Volume 13, Issue 1 , 2011 , Pages 43-50 ; 16087046 (ISSN) ; Hassanpour Ezatti, M ; Navidi, H ; Abachi, T ; Sharif University of Technology
2011
Abstract
Introduction: Today, Fuzzy expert systems have helped physicians in cases of uncertainty in medical decision making for prescribing drugs. Narrowing of coronary heart and reduction in heart blood flow are important causes of coronary heart disease (CHD). Control of blood lipid level is a routine treatment in CHD patients. But damage to liver is a common side effect of lipid lowering drug medication. Measurement of plasma Alanine aminotransferase level is considered as a marker of liver damage. The aim of this study was to determination of optimal dose of atorvastatin using Fuzzy expert system. Materials and Methods: in this study, Fuzzy expert system based on drug dose determination was...
A metabonomics study on crohn's disease using nuclear magnetic resonance spectroscopy
, Article HealthMED ; Volume 6, Issue 11 , July , 2012 , Pages 3577-3583 ; 18402291 (ISSN) ; Kyani, A ; Nejad, M. R ; Rezaye Tavirani, M ; Naderi, N ; Zali, M. R ; Tafazzoli, M ; Oskouie, A. A ; Sharif University of Technology
2012
Abstract
Objective: Crohn's disease (CD) is one the important illnesses can affect any part of the gastrointestinal tract. CD is not easily diagnosed using the clinical tests. Thus, the discovery of proper methods would be a major step towards CD diagnosis. The aim of this study was to seek the metabolic biomarkers causes of CD compare to control group. Materials and Methods: In present study, we employed metabolic profiling using proton nuclear magnetic resonance spectroscopy (1HNMR) to find metabolites in serum which are helpful for the diagnosis of CD. Classification of CD and healthy subject was done using classification and regression trees (CART). The metabolites that caused changes in people...
The metabolome profiling of obese and non-obese individuals: Metabolically healthy obese and unhealthy non-obese paradox
, Article Iranian Journal of Basic Medical Sciences ; Volume 23, Issue 2 , 2020 , Pages 186-194 ; Madani, N. H ; Ghoochani, B. F. N. M ; Safari Alighiarloo, N ; Khamseh, M. E ; Sharif University of Technology
Mashhad University of Medical Sciences
2020
Abstract
Objective(s): The molecular basis of “metabolically healthy obese” and “metabolically unhealthy non-obese” phenotypes is not fully understood. Our objective was to identify metabolite patterns differing in obese (metabolically healthy vs unhealthy (MHO vs MUHO)) and non-obese (metabolically healthy vs unhealthy (MHNO vs MUHNO)) individuals. Materials and Methods: This case-control study was performed on 86 subjects stratified into four groups using anthropometric and clinical measurements: MHO (21), MUHO (21), MHNO (22), and MUHNO (22). Serum metabolites were profiled using nuclear magnetic resonance (NMR). Multivariate analysis was applied to uncover discriminant metabolites, and enrichment...