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A comparative study of collagen matrix density effect on endothelial sprout formation using experimental and computational approaches
, Article Annals of Biomedical Engineering ; Volume 44, Issue 4 , 2016 , Pages 929-941 ; 00906964 (ISSN) ; Mohammadaliha, N ; Heilshorn, S. C ; Bauer, A. L ; Sharif University of Technology
Abstract
A thorough understanding of determining factors in angiogenesis is a necessary step to control the development of new blood vessels. Extracellular matrix density is known to have a significant influence on cellular behaviors and consequently can regulate vessel formation. The utilization of experimental platforms in combination with numerical models can be a powerful method to explore the mechanisms of new capillary sprout formation. In this study, using an integrative method, the interplay between the matrix density and angiogenesis was investigated. Owing the fact that the extracellular matrix density is a global parameter that can affect other parameters such as pore size, stiffness,...