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cell-injection
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Application of a new spherical super element in predicting the deformation of biological cells in microinjection
, Article Proceedings of the ASME Design Engineering Technical Conference, 28 August 2011 through 31 August 2011 ; Volume 7 , August , 2011 , Pages 41-49 ; 9780791854846 (ISBN) ; Ahmadian, M. T ; Sharif University of Technology
2011
Abstract
Biological cell injection is a sensitive and important work which is implemented in injection of foreign materials into individual cells. Microinjection is significantly developed in the field of drug discovery and genetics so predicting the behavior of cell in microinjection is remarkably important because a tiny excessive manipulation force can destroy the tissue of the biological cell. There are a few analytical methods available to simulate the cell injection, hence the numerical methods such as FEM are suitable to be used to model the microinjection. In this study, a new spherical super element is presented to model the biological cells and deformation of a specific cell under an...
Comparison of deformation analysis of a biological cell under an injection force using analytical, experimental and finite element methods and Artificial Neural Network
, Article ASME 2011 International Mechanical Engineering Congress and Exposition, IMECE 2011 ; Volume 2 , 2011 , Pages 499-507 ; 9780791854884 (ISBN) ; Ahmadian, M. T ; ASME ; Sharif University of Technology
Abstract
Biological cell injection is a sensitive and important work which is implemented in injection of foreign materials into individual cells. Microinjection is significantly developed in the field of drug discovery and genetics so predicting the behavior of cell in microinjection is remarkably important because a tiny excessive manipulation force can destroy the tissue of the biological cell. There are a few analytical methods available to simulate the cell injection, hence the numerical methods such as FEM are suitable to be used to model the microinjection. In this study, a new spherical super element is presented to model the biological cells and deformation of a specific cell under an...
Modeling and Manipulation of Intracytoplasmic Cell Injection
, M.Sc. Thesis Sharif University of Technology ; Ahmadian, Mohammad Taghi (Supervisor)
Abstract
The injection process on cell is a very accurate and sensitive operation. This method is used for several new invented approaches such as tracytoplasmic Cell Injection or drug delivery. Controlling the injection force in micro scale is one of the problems of mentioned operations. Current huge and expensive laboratorial devices are helping the operators to do injection operation with :nore success. In this study a simple and novel microelectromechanical (MEMS) mechanism for doing injection process automatically on the biological cells is proposed. In order to controlling this device properly, we should model and simulate the operation condition from initial position to final condition. This...
Deformation prediction of mouse embryos in cell injection experiment by a feedforward artificial neural network
, Article Proceedings of the ASME Design Engineering Technical Conference, 28 August 2011 through 31 August 2011 ; Volume 2, Issue PARTS A AND B , August , 2011 , Pages 543-550 ; 9780791854792 (ISBN) ; Ahmadian, M. T ; Vossoughi, G. R ; Sharif University of Technology
2011
Abstract
In this study, neural network models have been used to predict the mechanical behaviors of mouse embryos. In addition, sensitivity analysis has been carried out to investigate the influence of the significance of input parameters on the mechanical behavior of mouse embryos. In order to reach these purposes two neural network models have been implemented. Experimental data earlier deduced-by [Flückiger, M. (2004). Cell Membrane Mechanical Modeling for Microrobotic Cell Manipulation. Diploma Thesis, ETHZ Swiss Federal Institute of Technology, Zurich, WS03/04]-were collected to obtain training and test data for the neural network. The results of these investigations show that the correlation...