Sharif Digital Repository

Nowadays, M&S is critical as a powerful tool for human to fight against cancer. Skin cancer is one of the most widespread cancers and melanoma would be the most dangerous kind of it. In cancerous micro-environment, cancer cells interact with vasculature, and compete with normal cells over nutrients. This plays a major role in tumor progression pattern and speed. In recent years, a few multiscale models have been developed considering these phenomena. Such a model provides a platform for future researches, especially in drug effects prediction. A reliable simulation must satisfy the constraints and facts in the real world as much as possible. M&S credibility assessment is a major concern to... 

Cancer is refer to a class of diseases that create as the result of abnormal growth of cells and invasion of them to normal cells of human body, and annually cause the considerable percentage of death in the world. Because cancer can be considered as a complex system, various models presented to modeling and simulation of the behavior of it, using of different methods such as cellular automata, agent-based, game theory and other methods. Multi-agent simulation models as a special kind of agent-based models, is a method that used to simulate some real-world phenomena that usually contains many different components and interact using different and complex ways. Since the cells are located in...