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bone-marrow-transplantation
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Comparison of transplantation of bone marrow stromal cells (BMSC) and stem cell mobilization by granulocyte colony stimulating factor after traumatic brain injury in rat
, Article Iranian Biomedical Journal ; Volume 14, Issue 4 , Oct , 2010 , Pages 142-149 ; 1028852X (ISSN) ; Marzban, M ; Mehdizadeh, M ; Joghataei, M. T ; Khoei, S ; Pirhajati Mahabadi, V ; Laribi, B ; Tondar, M ; Moshkforoush, A ; Sharif University of Technology
2010
Abstract
Background: Recent clinical studies of treating traumatic brain injury (TBI) with autologous adult stem cells led us to compare effect of intravenous injection of bone marrow mesenchymal stem cells (BMSC) and bone marrow hematopoietic stem cell mobilization, induced by granulocyte colony stimulating factor (G-CSF), in rats with a cortical compact device. Methods: Forty adult male Wistar rats were injured with controlled cortical impact device and divided randomly into four groups. The treatment groups were injected with 2 × 106 intravenous bone marrow stromal stem cell (n = 10) and also with subcutaneous G-CSF (n = 10) and sham-operation group (n = 10) received PBS and "bromodeoxyuridine...
HLA alleles and haplotype frequencies in Iranian population
, Article Human Antibodies ; Volume 30, Issue 2 , 2022 , Pages 79-96 ; 10932607 (ISSN) ; Hussen, B. M ; Pashmforoush, S ; Akbari, M. T ; Arsang-Jang, S ; Nazer, N ; Hamidieh, A. A ; Hajifathali, A ; Dinger, M. E ; Sayad, A ; Dehaghi, M. O ; Sharif University of Technology
IOS Press BV
2022
Abstract
BACKGROUND: HLA genotyping is a prerequisite for selection of suitable donors in the process of bone marrow transplantation. METHODS: In the current study, the frequencies of HLA-A, -B, -C and -DRB1 alleles and A-B-C-DRB1 haplotypes were assessed in 855 healthy Iranian persons using a low-resolution sequence specific primer (SSP) kit. RESULTS: Frequencies were compared between 11 subpopulations including Armani, Balouch, Bandari, Turk, Turkaman, Arab, Fars, Kurd, Gilaki, Lor and Mazani. In total, 17 HLA-A alleles were detected, one of which (HLA-A*74) was present only among Lors. HLA-A*23 and -A*26 were the most frequent HLA-A alleles among Armanis. HLA-A*23 was also common among Turkamans....
CRISPR-Cas, a robust gene-editing technology in the era of modern cancer immunotherapy
, Article Cancer Cell International ; Volume 20, Issue 1 , September , 2020 ; Tafsiri, E ; Cho, W. C. S ; Ghaemi, A ; Sharif University of Technology
BioMed Central Ltd
2020
Abstract
Cancer immunotherapy has been emerged as a promising strategy for treatment of a broad spectrum of malignancies ranging from hematological to solid tumors. One of the principal approaches of cancer immunotherapy is transfer of natural or engineered tumor-specific T-cells into patients, a so called "adoptive cell transfer", or ACT, process. Construction of allogeneic T-cells is dependent on the employment of a gene-editing tool to modify donor-extracted T-cells and prepare them to specifically act against tumor cells with enhanced function and durability and least side-effects. In this context, CRISPR technology can be used to produce universal T-cells, equipped with recombinant T cell...