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biaxial-cyclic-stretch
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Endothelial cells morphology in response to combined wss and biaxial cs: introduction of effective strain ratio
, Article Cellular and Molecular Bioengineering ; Volume 13, Issue 6 , 2020 , Pages 647-657 ; Saidi, M. S ; Firoozabadi, B ; Sharif University of Technology
Springer
2020
Abstract
Introduction: Endothelial cells (ECs) morphology strongly depends on the imposed mechanical stimuli. These mechanical stimuli include wall shear stress (WSS) and biaxial cyclic stretches (CS). Under combined loading, the effect of CS is not as simple as pure CS. The present study investigates the morphological response of ECs to the realistic mechanical stimuli. Methods: The cell population is theoretically studied using our previous validated model. The mechanical stimuli on ECs are described using four parameters; WSS magnitude (0 to 2.0 Pa), WSS angle (− 50° to 50°), and biaxial CS in two perpendicular directions (0 to 10%). The morphology of ECs is reported using four parameters; average...