Sharif Digital Repository

The domino-Knoevenagele hetero-Dielse Alder reaction is an efficient synthesis of complex compounds like natural products from simple substrates and highly diverse molecules. In the first chapter, synthesis of pyran, pyranopyran, pyrano-thiopyran heterocycles and [6,5] pyranopyrrole derivatives are achieved via domino Knoevenagele hetero-Dielse Alder reaction of O-acrylated and o- propargylated salicylaldehyde derivatives with thiooxindole and 4- hydroxyl dithiocoumarin. We discovered a new and efficient synthesis of a great variety of thiopyrano indole annulated benzo -δ-sultones via domino Knoevenagele hetero-Dielse Alder reaction of thiooxindole derivatives and (E)-2-formylphenyl... 

We have reported a new and efficient synthesis of a broad spectrum of heterotetracyclic thiopyranoindole via knovenagel hetero diels alder reaction.Fused pyrimidines have attracted considerable attention in synthetic organic chemistry because of their wide range of biological activities pharmaceutical and therapeutic properties, and antibacterial, antiviral, antitumor, and anti-inflammatory activities. We have reported a new efficient method for synthesis of pyrimidines fused to coumarine, uracile, cyclohexane and triamino pyrimidine structures. The major benefits of the current study are high yields, short reaction times, mild reaction conditions and available materials..We have also... 

The one pot, three component 1,3-dipolar cycloaddition reaction of azomethine ylides with a series of new dipolarophiles (E)-3 -benzylidene- indolin-2 -ones in methanol under the reflux condition yields ,3′-dispiropyrrolidine oxindole library. The product is produced with high regioselectivity. Catalyst free, excellent yield , easy workup process, short reaction time, and convenient operation are the characteristics of this procedure. NMR and X-ray are used to determine the structure and stereochemistry of cycloadduct products.
 

Part 1
1,3-dipolar cycloaddition reactions offer convenient routes for the construction of a variety of five-membered heterocycles. This thesis represents a simple synthetic method via 1,3-dipolar cycloaddition reaction to prepare a novel class of spiro pyrrolidines and spiro pyrrolizidines which exhibit many biological activities. Non-stabilized azomethine ylides which generated in situ by the decarboxylative condensation of ninhydrin with proline and sarcosine were used as a 1,3-dipoles. On the other hand, chalcone and its derivatives with an impressive array of pharmacological activities were the dipolarophiles in these reactions. The reactions were carried out through reflax... 

1,3-Dipolar cycloaddition reactions constitute one of the most fundamental reactions for construction of five-membered heterocyclic compounds Spiro and dispirooxindoles have become important synthetic targets as these structural frameworks form the core units of many naturally occurring molecules that possess abundant biological activities .In this report we used (E)-Aryl ideneindolinones as unusual dipolarophiles for synthesis of dispirooxindoles. In follow different bifunctional nucleophiles for example 1,3-dicarbonyl, phenol, thioindole can be used in synthesis of benzoxazocines We have reported a new and efficient synthesis of benzoxazocines via unique tandem 1,3-dinucleophilic addition...