Loading...
Search for:
asparagine
0.008 seconds
Biological Removal of Acrylamide Produced During the Baking Process
, M.Sc. Thesis Sharif University of Technology ; Alemzadeh, Iran (Supervisor)
Abstract
In recent year's acrylamide as a suspected substance for tumor growth has been studied. In some researches this topic is mentioned that acrylamide is produced by the reaction of asparagine and natural sugars. This reaction takes place only at very high temperatures during the heating process. The maximum amount of this substance is determined in fried potato products. In this study, a response surface methodology (RSM) 5-level-3-factor face centre central-composite design (FCCCD) was applied to envestigate the effects of asparaginase (300-900 U/kg of flour), baking temperature (230-280 °c) and baking time (13-16 min) on acrylamide (AA) formation in yeast-leavened wheat bread and...
Asparaginase Effect on Acrylamide Reduction During Food Processing
, M.Sc. Thesis Sharif University of Technology ; Aalemzadeh, Iran (Supervisor) ; Vossoughi, Manoochehr (Supervisor)
Abstract
In recent year's acrylamide as a suspected substance for tumor growth has been studied. In some researches this topic is mentioned that acrylamide is produced by the reaction of asparagine and natural sugars. This reaction takes place only at very high temperatures during the heating process. The maximum amount of this substance is determined in fried potato products. The purpose of this study was determined to remove and reduce acrylamide formation during frying of potato. Acrylamide production when it was blanching and when it was dipped in the enzyme solution of asparaginase was examined. When potato pieces were placed in a commercial enzyme solution 200 lU/ml, acrylamide formation was...
NMR spectroscopy-based metabolomic study of serum in sulfur mustard exposed patients with lung disease
, Article Biomarkers ; Volume 22, Issue 5 , 2017 , Pages 413-419 ; 1354750X (ISSN) ; Arefi Oskouie, A ; Rezaei Tavirani, M ; Aliannejad, R ; Taheri, S ; Fathi, F ; Naseri, M. T ; Sharif University of Technology
Taylor and Francis Ltd
2017
Abstract
Sulfur mustard (SM) is a vesication chemical warfare agent for which there is currently no antidote. Despite years of research, there is no common consensus about the pathophysiological basis of chronic pulmonary disease caused by this chemical warfare agent. In this study, we combined chemometric techniques with nuclear magnetic resonance (NMR) spectroscopy to explore the metabolic profile of sera from SM-exposed patients. A total of 29 serum samples obtained from 17 SM-injured patients, and 12 healthy controls were analyzed by Random Forest. Increased concentrations of seven amino acids, glycerol, dimethylamine, ketone bodies, lactate, acetate, citrulline and creatine together with the...
Investigating the effects of amino acid-based surface modification of carbon nanoparticles on the kinetics of insulin amyloid formation
, Article Colloids and Surfaces B: Biointerfaces ; Volume 176 , 2019 , Pages 471-479 ; 09277765 (ISSN) ; Yahyazadeh, A ; Sharif University of Technology
Elsevier B.V
2019
Abstract
Surface functionality of nanoparticles has been pivotal in defining interactions of nanoparticles and biomolecules. To explore various functionalities on the surface of nanoparticle through a facile procedure, various carbon-based nanoparticles, modified with a specific natural amino acid, were synthesized; the amino acids were chosen in order that almost all classes of amino acids were included. After characterizations of the nanoparticles using several spectroscopic methods, the effects of surface modification of nanoparticles were examined against amyloid formation, exploiting insulin as a model amyloidogenic polypeptide. Although most amino acids afforded carbon nanoparticles, only...
The metabolome profiling of obese and non-obese individuals: Metabolically healthy obese and unhealthy non-obese paradox
, Article Iranian Journal of Basic Medical Sciences ; Volume 23, Issue 2 , 2020 , Pages 186-194 ; Madani, N. H ; Ghoochani, B. F. N. M ; Safari Alighiarloo, N ; Khamseh, M. E ; Sharif University of Technology
Mashhad University of Medical Sciences
2020
Abstract
Objective(s): The molecular basis of “metabolically healthy obese” and “metabolically unhealthy non-obese” phenotypes is not fully understood. Our objective was to identify metabolite patterns differing in obese (metabolically healthy vs unhealthy (MHO vs MUHO)) and non-obese (metabolically healthy vs unhealthy (MHNO vs MUHNO)) individuals. Materials and Methods: This case-control study was performed on 86 subjects stratified into four groups using anthropometric and clinical measurements: MHO (21), MUHO (21), MHNO (22), and MUHNO (22). Serum metabolites were profiled using nuclear magnetic resonance (NMR). Multivariate analysis was applied to uncover discriminant metabolites, and enrichment...
Green products from herbal medicine wastes by subcritical water treatment
, Article Journal of Hazardous Materials ; Volume 424 , 2022 ; 03043894 (ISSN) ; Tavakoli, O ; Sarkhanpour, R ; Sajadi, S. M ; Zarrintaj, P ; Rabiee, N ; Akhavan, O ; Lima, E. C ; Saeb, M. R ; Sharif University of Technology
Elsevier B.V
2022
Abstract
Herbal medicine wastes (HMWs) are byproducts of medicine factories, which are mainly landfilled for their environmental problems. Only bearing in mind the contamination and concerns caused by the COVID-19 pandemic and environmental emissions, the worth of herbal medicine wastes management and conversion to green products can be understood. In this work, subcritical water treatment was carried out batch-wise in a stainless tube reactor in the pressure range of 0.792–30.0 MPa, varying the temperature (127–327 °C) and time (1–60 min) of extraction. This resulted in new and green material sources, including organic acids, amino acids, and sugars. Amazingly, at very low extraction times (below 5...