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anticonvulsants
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Association between human leukocyte antigens and cutaneous adverse drug reactions to antiepileptics and antibiotics in the Iranian population
, Article Dermatologic Therapy ; Volume 35, Issue 5 , 2022 ; 13960296 (ISSN) ; Rostami, A ; Firooz, A ; Esmaili, N ; Ghiasi, M ; Lajevardi, V ; Amirzargar, A. A ; Sheykhi, I ; Khamesipour, A ; Akhdar, M ; Sharif University of Technology
John Wiley and Sons Inc
2022
Abstract
In this case–control study, class І and ІІ human leukocyte antigen (HLA) alleles in Iranian patients with benign and severe cutaneous adverse drug reactions (CADRs) due to aromatic anticonvulsants and antibiotics were evaluated. Patients diagnosed with CADRs (based on clinical and laboratory findings) with a Naranjo score of ≥ 4 underwent blood sampling and HLA-DNA typing. The control group comprised 90 healthy Iranian adults. Alleles with a frequency of more than two were reported. Deviations from Hardy–Weinberg equilibrium were not observed. Eighty patients with CADRs including 54 females and 26 males with a mean age of 41.49 ± 16.08 years were enrolled in this study. The culprit drugs...
Highly sensitive voltammetric determination of lamotrigine at highly oriented pyrolytic graphite electrode
, Article Bioelectrochemistry ; Volume 84 , 2012 , Pages 38-43 ; 15675394 (ISSN) ; Shahrokhian, S ; Sharif University of Technology
2012
Abstract
The electrochemical behavior of lamotrigine (LMT) at the pyrolytic graphite electrode (PGE) is investigated in detail by the means of cyclic voltammetry. During the electrochemical reduction of LMT, an irreversible cathodic peak appeared. Cyclic voltammetric studies indicated that the reduction process has an irreversible and adsorption-like behavior. The observed reduction peak is attributed to a two-electron process referring to the reduction of azo group. The electrode showed an excellent electrochemical activity toward the electro-reduction of LMT, leading to a significant improvement in sensitivity as compared to the glassy carbon electrode. The results of electrochemical impedance...