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On the optimality of the genetic code, with the consideration of termination codons
, Article BioSystems ; Volume 77, Issue 1-3 , 2004 , Pages 163-173 ; 03032647 (ISSN) ; Nejad, H. A ; Torabi, N ; Sharif University of Technology
2004
Abstract
The existence of nonrandom patterns in codon assignments is supported by many statistical and biochemical studies. The canonical genetic code is known to be highly efficient in minimizing the effects of mistranslation errors and point mutations. For example, it is known that when an error induces the conversion of an amino acid to another, the biochemical properties of the resulting amino acid are usually very similar to that of the original. Prior studies include many attempts at quantitative estimation of the fraction of randomly generated codes which, based upon load minimization, score higher than the canonical genetic code. In this study, we took into consideration both the relative...