Sharif Digital Repository

This study is an effort to quantify potential cost savings of children's walking, as a form of active travel to school. The data were collected in Tehran, from a cross-sectional cohort of more than 4700 high school and middle school students. This study looks at a wide range of policy sensitive variables, such as safety and distance to school in various scenarios. The findings indicate if the safety concerns of parents associated with their children walking to school are alleviated, the direct and indirect annual costs of obesity decreases by US$719 per student. Further, a 1% decrease in the distance from home to school diminishes the annual per capita health costs associated with obesity by... 

This study is an effort to quantify potential cost savings of children's walking, as a form of active travel to school. The data were collected in Tehran, from a cross-sectional cohort of more than 4700 high school and middle school students. This study looks at a wide range of policy sensitive variables, such as safety and distance to school in various scenarios. The findings indicate if the safety concerns of parents associated with their children walking to school are alleviated, the direct and indirect annual costs of obesity decreases by US$719 per student. Further, a 1% decrease in the distance from home to school diminishes the annual per capita health costs associated with obesity by... 

Investigation of nanomachine swarm motion is useful in the design of molecular transportation systems as well as in understanding the assembly process on the surface. Here, we evaluate the motion of the clusters of nanocars on graphene surfaces, using molecular dynamics (MD) simulations. The mechanism of motion of single nanocars is evaluated by considering the rotation of the wheels, direction of the nanocars’ speed and comparing the characteristics of the surface motion of nanocars and similar absorbed molecules. The mentioned analyses reveal that, in the thermally activated surface motion of the nanocars, sliding movements are the dominant mode of motion. A coarse grained (CG) model is... 

Cellular internalization of inorganic, lipidic and polymeric nanoparticles is of great significance in the quest to develop effective formulations for the treatment of high morbidity rate diseases. Understanding nanoparticle–cell interactions plays a key role in therapeutic interventions, and it continues to be a topic of great interest to both chemists and biologists. The mechanistic evaluation of cellular uptake is quite complex and is continuously being aided by the design of nanocarriers with desired physico-chemical properties. The progress in biomedicine, including enhancing the rate of uptake by the cells, is being made through the development of structure–property relationships in... 

Biologic products are large molecules such as proteins, peptides, nucleic acids, etc., which have already produced many new drugs for clinical use in the last decades. Due to the inherent challenges faced by biologics after oral administration (e.g., acidic stomach pH, digestive enzymes, and limited permeation through the gastrointestinal tract), several alternative routes of administration have been investigated to enable sufficient drug absorption into systemic circulation. This review describes the buccal, sublingual, pulmonary, and transdermal routes of administration for biologics with relevant details of the respective barriers. While all these routes avoid transit through the...