Sharif Digital Repository

In this study, a catalyst-free Mannich reaction is applied for synthesis of 1,3-oxazines as an important class of biologically active compounds. In order to consider environmental application a mixture of water and ethanol is selected as a solvent for the reaction of 2,7-dihydroxynaphthalene with formaldehyde and an amine. Primary consideration of substitution effect on the reaction revealed that aniline and its derivatives with electron-donating substituent and halogens, cause higher yield. Aliphatic amines are not good substrate for this reaction with the exception of benzyl amine  

Dithiocarbamates are a group of compounds that nowadays have been used extensively in pharmaceutical agents, organicsynthesis and as fungicides in agriculture.We haveshown, an efficient. regiospecific method for the synthesis of cyclic dithiocarbamates by one-pot three-component cascade reaction of an amine, CS2 and α,β-unsaturated aldehyde via Michael addition/hemiamination reaction in watre under a mild and green procedure with excellent yields and complete regioselectivity  

The reaction of α-haloketones with a variety of dithiocarbamate derivatives for the synthesis of various 2-alkylthiothiazole heterocyclic compounds was investigated in this thesis. To this end, different dithiocarbamates were initially synthesized through the reaction of amines, carbon disulfide and various alkyl halides; then, these dithiocarbamates were reacted with α-bromoketones (bromoacetophenone and chloroacetone) resulting in the formation of range of 2-alkyl thiothiazoles. To optimize the reaction conditions, ethanol and water were tested as solvents in the presence of ZrCl4 as catalyst. According to the data obtained, ethanol was selected as the optimum solvent using ZrCl4 as... 

In this work Nitroolefins were made by aromatic aldehydes consisting of electron withdrawing and electron donor groups. Afterward β-Bromo-β-nitrostyrenes were produced from interaction between nitroolefins and brom, at suitable temperature. After providing ingredients, micheal reaction (Friedel-crafts Pseudo-alkylation) between nitroolefins and various nucleophiles such as indoles was investigated. Finally desired micheal products were achived with high efficiency  

Dithiocarbamate is one of the most useful components in the science of chemistry. They are used not only in agriculture as fungicides but also in photochemistry in order to determine and analyse NO in biological processes as well as in polymerization routes. Dithiocarbamates which are known as bidentate ligands with high yield are applied in many fields such as producing chemical drugs, functioning as intermediates in organic synthesis, protecting groups in peptide synthesis as well as highly chelating ligands. Regarding the high practically of dithiocarbamates and by focusing on their synthesis process, we have applied them as bidentate ligands. Cinnamaldehyde was condensed in ethanol with... 

This project investigates on synthesis of β-amino carbonyl compounds with new approach to become closer to green chemistry principals.In this project, we investigated the synthesis of β-amino carbonyl compounds with aromatic amines and electron deficient alkenes in the Michael reaction using boric acid and glycerol in water as a green media. High yields of the products and easy handling are some advantages of this procedure. Also, we investigated the Michael reaction in different solvents and temperatures but gave better results in the aqueous media. Moreover, thiomorpholine derivatives were synthesized using this method to give excellent yield.
 

Development of strategically important processes which are environmentally benign with simple methodology and work-up by low toxic material is currently reciving considerable attention.In recent years, dithiocarbamates (DTCs) and their synthesis with a green procedure have received many attention because of their undeniable applications.These synthetic compounds play important roles either in academia and industry. Here a simple, efficient and regiospecific method for synthesis of dithiocarbamates is described by one-pot three-component reaction of an amine, CS2 and alkyl vinyl ether via Markovnikov addition reaction in poly ethylene glycol (PEG) under a mild and green procedure with... 

This research project contains two parts that investigating new approaches for becoming closer to green chemistry principals is clear in it. In the first part we tried to synthesis dithiocarbamate salts using aromatic amins and than Michael addition of them to prepare bifunctional dithiocarbamats. But we found ?-thiols as final product. In the second part of this project, we investigated the regioselective epoxide ring opening with aromatic amines by using boric acid and glycerol in water as a green media. Corresponding ?-amino alcohols were obtained with excellent yields and considerable regioselectivity. High yields of the products, mild reaction conditions, using green catalyst and water... 

In the first section, for the first time, a reaction of dithiocarbamic acid salts with carbonyl compounds has been investigated in the presence of BF3.OEt2. The reaction is temperature dependent meaning that the reaction gives two different products at low and high temperatures. At 15-20 0C, the 2-iminium-1,3-dithietane is the main product.As the reaction temperature goes up, formation of gem-bis(dithiocarbamates) is dominant.In addition, deprotection of gem-bis(dithiocarbamates) was investigated by using of nitric acid as the only deprotecting agent. The structure of a 2-iminium-1,3-dithietane was confirmed by X-ray crystallographic analysis.
In the second and third sections, in our aim... 

Dithiocabamates are valuable compounds due to their wide application as herbicides, fungicides, antitumor and etc. Another aspect of dithiocarbamates is their application in coordination chemistry. In this project, 3-((pyridin-2-yl) methyl amino) propane nitrile was prepared via Michael addition reaction of 1-methyl¬amino¬pyridine and acrylonitrile in water. Then this compound was converted to its potassium dithiocarbamate salt via treatment with carbon disulfide in the presence of potassium hydroxide in tetrahydrofuran. The prepared ligand was used in complexation with metal salts of Zn, Hg, Ni and Sn to prepare their dithiocarbamate complexes. The structure of complexes was elucidated by... 

This projct includes the following sections: In the first section, Michael addition reaction of anthrone to nitroolefins is described in water without using any catalyst to prepare 9-(2-nitro-1-arylethyl)anthracene-10(9H)-ones. This method is green, efficient and gives high yields of products. The solvent effect is also investigated. In the second section, Considerable efforts have been directed in recent years towards the transition metal complex catalyzed oxidation of organic compounds such as olefins, sulfides, benzylics alcohols and phenolics. And due to the various advantages of supported heterogeneous catalysts and in our aim to develop a simple, more efficient and eco-friendly...