Sharif Digital Repository

In this paper, entropy generation in heat exchangers used in Indirect Evaporative Coolers (IDECs) is studied. First, expressions for the rate of entropy generation in tube-type and plate-type cross-flow heat exchangers used as IDECs are obtained. Then, by introducing appropriate geometric constraints and employing thermohydraulic design equations, the variation of the rate of entropy generation within the heat exchangers is investigated. The maximum EER, outlet temperatures and the optimum sizes are obtained for several cases. The results of several experiments conducted on an optimum tube-type experimental prototype are presented and compared with the numerical data. Copyright © 2009... 

In this work, two important opioid antagonists, naltrexone and oxycodone, were prepared from thebaine and were characterized by IR, 1H NMR and 13C NMR spectroscopy. Moreover, computational NMR and IR parameters were obtained using density functional theory (DFT) at B3LYP/6-311++G* * level of theory. Complete NMR and vibrational assignment were carried out using the observed and calculated spectra. The IR frequencies and NMR chemical shifts, determined experimentally, were compared with those obtained theoretically from DFT calculations, showed good agreements. The RMS errors observed between experimental and calculated data for the IR absorptions are 85 and 105 cm-1, for the 1H NMR peaks are... 

The Nafion ionomer affects the efficiency of the platinum (Pt) catalyst by blocking the active sites thereby restricting the gas permeability of the catalyst layer; but, there is a limitation in the quantity of Nafion ionomer that needs to be added without affecting the cell performance. Sulfonation of carbon-supported catalysts as mixed electronic and protonic conductors has been reported to be an efficient way to increase the triple-phase boundaries. In order to improve the utilization and activity of cathodic catalysts in the oxygen reduction reaction (ORR), Pt nanoparticles were loaded on a mixture of Vulcan XC-72R and MWCNTs, which were functionalized in a mixture of 96% sulfuric acid... 

In this paper, heat and mass transfer phenomena occurring simultaneously in falling film generator of absorption chillers have been studied. The analysis is based on the laminar flow of an Li/Br solution over a horizontal single tube and tube bundle having a constant tube wall temperature. The effect of boiling has been ignored. An extensive numerical code is provided to calculate the heat transfer coefficient and the rate of evaporation. A parametric study is performed on the coefficient of heat transfer and the evaporation flux of the refrigerant. Dimensionless correlations are obtained to calculate the heat transfer coefficient on the horizontal tube and tube bundle. The comparison... 

The objective of this paper is to provide optimization of falling film Li/Br solution on a horizontal single tube based on minimization of entropy generation. Flow regime is considered to be laminar, the effect of boiling has been ignored and wall temperature is constant. Velocity, temperature and concentration distributions are numerically determined and dimensionless correlations are obtained for predicting the average heat transfer coefficient and average evaporation factor on the horizontal tube. Thermodynamic imperfection due to passing lithium bromide solution is attributed to non-isothermal heat transfer; fluid flow friction and mass transfer irreversibility. Scale analysis shows that... 

(Liquid + liquid) equilibrium (LLE) data for the ternary systems (heptane + toluene + 1-ethyl-3-methylpyridinium ethylsulfate) and (heptane + benzene + 1-ethyl-3-methylpyridinium ethylsulfate) were measured at T = 298.15 K and atmospheric pressure. The selectivity and aromatic distribution coefficients, calculated from the equilibrium data, were used to determine if this ionic liquid can be used as a potential extracting solvent for the separation of aromatic compounds from heptane. The consistency of tie-line data was ascertained by applying the Othmer-Tobias and Hand equations  

Cell culture feeds optimization is a critical step in process development of pharmaceutical recombinant protein production. Amino acids are the basic supplements of mammalian cell culture feeds with known effect on their growth promotion and productivity. In this study, we reported the implementation of the Plackett-Burman (PB) multifactorial design to screen the effects of amino acids on the growth promotion and productivity of a Chinese hamster ovary DG-44 (CHO-DG44) cell line producing bevacizumab. After this screening, the amino acid combinations were optimized by the response surface methodology (RSM) to determine the most effective concentration in feeds. Through this strategy, the... 

Background: Chinese hamster ovary (CHO) cell line is considered as the most common cell line in the biopharmaceutical industry because of its capability in performing efficient post-translational modifications and producing the recombinant proteins, which are similar to natural human proteins. The optimization of the upstream process via different feed strategies has a great impact on the target molecule expression and yield. Methods: To determine and understand the molecular events beneath the feed effects on the CHO cell, a label-free quantitative proteomic analysis was applied. The proteome changes followed by the addition of a designed amino acid feed to the monoclonal antibody producing...