Sharif Digital Repository

Predicting the Amino Acids that have a catalytic effect in the enzymes, is a big step in appointing the activity of the enzymes and classifying them. This is a very challenging job, because an Amino Acid can appear in a variety of active sites.The biological activity of a protein usually depends on the existence of a small number of Amino Acids. Detecting these Amino Acids from the sequence of Amino Acids has many applications. Usually, the Amino Acids that are preserved are known as the Amino Acids that build up the active site, but the algorithms for finding the preserved Amino Acids are much more complex. There are a lot of algorithms for predicting the active sites of Amino Acids, but... 

Gene regulatory modeling in different species is one of the main aims of Bioinformatics. Regarding the limitations of the data available and the perspectives which should be taken into account for modeling such networks, proposed methods up to now have not yet been successful in yielding a comprehensive model. In one of the recent researches, the Gene regulation process is considered as a nonlinear dynamic stochastic process and described by state space equations. Afterwards, in order for the unknown parameters to be estimated, Extended Kalman Filtering is used. In this thesis, first of all, Gene complexes are taken into consideration instead of genes and afterwards, Extended Kalman...